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G., and Zlotnick, A

Thus, when a drug is metabolized by both phase I and phase II enzymes, the rate limiting step will occur during the phase I reaction

[17] Johns, D

Prog Neurobiol 88, 221-245

Fig 1 suggests that this increase in total glutathione pool appears to mostly result from increased GSH bound to plasma proteins, though GSH in erythrocyte lysate and GSSG bound to plasma proteins also contribute to this